SrasV1, Main, Exploration, bibRecord, 004D66

Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters

Identifieur interne : 004D66 ( Main/Exploration ); précédent : 004D65; suivant : 004D67

Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters

Auteurs : Anjeanette Roberts [États-Unis] ; Leatrice Vogel [États-Unis] ; Jeannette Guarner [États-Unis] ; Norman Hayes [États-Unis] ; Brian Murphy [États-Unis] ; Sherif Zaki [États-Unis] ; Kanta Subbarao [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : Pascal:05-0103174

Descripteurs français

KwdFr :
- Animaux, Cricetinae, Femelle, Humains, Mesocricetus, Modèles animaux de maladie humaine, Poumon (anatomopathologie), Poumon (virologie), Réplication virale, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Trachée (anatomopathologie), Trachée (virologie), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère, Trachée.
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Poumon, Syndrome respiratoire aigu sévère, Trachée.
Pascal (Inist)
- Animaux, Coronavirus, Cricetinae, Femelle, Hamster, Grave, Humains, Malade état grave, Aigu, Mesocricetus, Modèles animaux de maladie humaine, Réplication virale, Voie respiratoire, Animal, Microbiologie, Virologie, Syndrome respiratoire aigu sévère, Forme grave.

English descriptors

KwdEn :
- Acute, Animal, Animals, Coronavirus, Cricetinae, Critically ill, Disease Models, Animal, Female, Hamster, Humans, Lung (pathology), Lung (virology), Mesocricetus, Microbiology, Respiratory tract, SARS Virus (pathogenicity), SARS Virus (physiology), Severe, Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Trachea (pathology), Trachea (virology), Virology, Virus Replication.
MESH :
- pathogenicity : SARS Virus.
- pathology : Lung, Severe Acute Respiratory Syndrome, Trachea.
- physiology : SARS Virus.
- virology : Lung, Severe Acute Respiratory Syndrome, Trachea.
- Animals, Cricetinae, Disease Models, Animal, Female, Humans, Mesocricetus, Virus Replication.

Abstract

Small animal models are needed in order to evaluate the efficacy of candidate vaccines and antivirals directed against the severe acute respiratory syndrome coronavirus (SARS CoV). We investigated the ability of SARS CoV to infect 5-week-old Golden Syrian hamsters. When administered intranasally, SARS CoV replicates to high titers in the lungs and nasal turbinates. Peak replication in the lower respiratory tract was noted on day 2 postinfection (p.i.) and was cleared by day 7 p.i. Low levels of virus were present in the nasal turbinates of a few hamsters at 14 days p.i. Viral replication in epithelial cells of the respiratory tract was accompanied by cellular necrosis early in infection, followed by an inflammatory response coincident with viral clearance, focal consolidation in pulmonary tissue, and eventual pulmonary tissue repair. Despite high levels of virus replication and associated pathology in the respiratory tract, the hamsters showed no evidence of disease. Neutralizing antibodies were detected in sera at day 7 p.i., and mean titers at day 28 p.i. exceeded 1:400. Hamsters challenged with SARS CoV at day 28 p.i. were completely protected from virus replication and accompanying pathology in the respiratory tract. Comparing these data to the mouse model, SARS CoV replicates to a higher titer and for a longer duration in the respiratory tract of hamsters and is accompanied by significant pathology that is absent in mice. Viremia and extrapulmonary spread of SARS CoV to liver and spleen, which are seen in hamsters, were not detected in mice. The hamster, therefore, is superior to the mouse as a model for the evaluation of antiviral agents and candidate vaccines against SARS CoV replication.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Animal</term>
<term>Animals</term>
<term>Coronavirus</term>
<term>Cricetinae</term>
<term>Critically ill</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Hamster</term>
<term>Humans</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mesocricetus</term>
<term>Microbiology</term>
<term>Respiratory tract</term>
<term>SARS Virus (pathogenicity)</term>
<term>SARS Virus (physiology)</term>
<term>Severe</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Trachea (pathology)</term>
<term>Trachea (virology)</term>
<term>Virology</term>
<term>Virus Replication</term>
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<term>Cricetinae</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mesocricetus</term>
<term>Modèles animaux de maladie humaine</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Réplication virale</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Trachée (anatomopathologie)</term>
<term>Trachée (virologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Syndrome respiratoire aigu sévère</term>
<term>Trachée</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Trachea</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
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<term>Syndrome respiratoire aigu sévère</term>
<term>Trachée</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Trachea</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cricetinae</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Mesocricetus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus</term>
<term>Cricetinae</term>
<term>Femelle</term>
<term>Hamster</term>
<term>Grave</term>
<term>Humains</term>
<term>Malade état grave</term>
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<term>Modèles animaux de maladie humaine</term>
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<term>Voie respiratoire</term>
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<term>Microbiologie</term>
<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Small animal models are needed in order to evaluate the efficacy of candidate vaccines and antivirals directed against the severe acute respiratory syndrome coronavirus (SARS CoV). We investigated the ability of SARS CoV to infect 5-week-old Golden Syrian hamsters. When administered intranasally, SARS CoV replicates to high titers in the lungs and nasal turbinates. Peak replication in the lower respiratory tract was noted on day 2 postinfection (p.i.) and was cleared by day 7 p.i. Low levels of virus were present in the nasal turbinates of a few hamsters at 14 days p.i. Viral replication in epithelial cells of the respiratory tract was accompanied by cellular necrosis early in infection, followed by an inflammatory response coincident with viral clearance, focal consolidation in pulmonary tissue, and eventual pulmonary tissue repair. Despite high levels of virus replication and associated pathology in the respiratory tract, the hamsters showed no evidence of disease. Neutralizing antibodies were detected in sera at day 7 p.i., and mean titers at day 28 p.i. exceeded 1:400. Hamsters challenged with SARS CoV at day 28 p.i. were completely protected from virus replication and accompanying pathology in the respiratory tract. Comparing these data to the mouse model, SARS CoV replicates to a higher titer and for a longer duration in the respiratory tract of hamsters and is accompanied by significant pathology that is absent in mice. Viremia and extrapulmonary spread of SARS CoV to liver and spleen, which are seen in hamsters, were not detected in mice. The hamster, therefore, is superior to the mouse as a model for the evaluation of antiviral agents and candidate vaccines against SARS CoV replication.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Géorgie (États-Unis)</li>
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<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name>
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<name sortKey="Guarner, Jeannette" sort="Guarner, Jeannette" uniqKey="Guarner J" first="Jeannette" last="Guarner">Jeannette Guarner</name>
<name sortKey="Hayes, Norman" sort="Hayes, Norman" uniqKey="Hayes N" first="Norman" last="Hayes">Norman Hayes</name>
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<name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
</country>
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</record>

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Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters

Severe acute respiratory syndrome coronavirus infection of Golden Syrian hamsters

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Abstract

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